所属部门：食品科学与工程学院

　　职务/职称：教授

　　荣誉：博士生导师

　　电子邮件：nsbai@nwu.edu.cn

　　个人简介

　　白乃生教授多年来在国内外一直从事天然产物化学研究工作。主持自然基金面上项目等多项科研项目。1984年获延安大学化学专业学士学位。 1992 年获中科院上海药物研究所天然产物专业硕士学位，2003年获美国罗格斯大学(Rutgers, The State University of New Jersey)天然产物化学专业博士学位。2002 年进入美国Naturex Inc.任高级研究员。2011 年5 月回国进入西北大学化工学院制药工程系工作任特评教授。

　　研究成果

　　PATENTS专利

　　1. Ho, C. T.; Bai, N. S. Slavik Dushenkov; Zignag Dong; Ann M. Bode. Patent
WO 06073457A2. Bioactive compounds and methods of uses there of Rabdosia
rubescens.

　　2. Ho, C. T.; Bai, N. S.; Pan, M.H.; Slavik Dushenkov. U.S. Patent WO
2007109119, Antitumor Neobritannilactone B and acetyl neobritannilactone B.

　　3. He, Kan; Roller, Marc; Bily, Antonie; Bai, Naisheng; Dikansky, Jacques;
Ibarra, Alvin. (USA). Patent US 2009117214; WO2009061849. Extract of Fraxinus
excelsior seeds for promoting insulin sensitivity.

　　4. Ho, C. T.; Mohamed, R.; DiPaola, R. S.; Ghai, G.; Rosen, R. T.; Bai, N. S. U.S. Patent 6,627,623 B2 Inducing Cell Apoptosis and Treating Cancer Using 1-O-Acetylbritannilactone or 1,6-O,O-Diacetylbritannilactone.

　　5. Ho, C. T.; Mohamed, R.; DiPaola, R. S.; Ghai, G.; Rosen, R. T.; Bai, N. S. Patent WO/2002/067964, Compositions containing Inula britannica extracts for cancer prevention and treatment.

　　6. Qun Yi Zheng; Bo Lin Zheng; Kan He; Bao Liang Cui; Bai, N. S. Weight
Loss Composition. Patent WO 06017157A1. February 16, 2006.

　　7. He, Kan; Roller, Marc; Bai, Naisheng; Dikansky, Jacques; Ibarra, Alvin.
Patent WO 2011047321 A1. Extract of Rosmarinus officinalis L. leaves for
pharmaceutical applications.

　　8.
白乃生，刘庆超，白璐，张丽，郭甜甜，崔雪芹，吴勇，田潇，江咪，张鑫鑫，一种标准化红枣提取物及其制备和分析方法，中国，201410759326.2.。

　　9.
白乃生，刘庆超，张云婷，薛伟明，白璐，张丽，郭甜甜，温慧云，郭森，一种大叶白蜡树种子中降血糖物质裂环烯醚萜苷类化合物的提取制备技术，中国，201410759327.7.。

　　10.
白乃生，刘庆超，白璐，杨新文，张丽，郭甜甜，侯满伟，郭静，崔雪芹.，一种标准化苹果提取物及其制备和分析方法，中国，201410759305.0.。

　　11.
白乃生，张建春，刘庆超，何锦凤，张丽，白璐，侯宇飞，张海，刘雪英，张生勇，汉麻新化合物及其分离方法，中国，201410759356.3.(授权)。

　　12. 白乃生，白璐, 刘庆超, 张丽，郭森, 张鑫鑫，郭静. 一种沙旋复花中标准化提取物及其分析方法和应用,
中国，201610066033.5.

　　13. 白乃生，白璐, 吴勇，刘庆超, 张丽，郭森,崔雪琴，江咪. 一种红枣树叶标准化提取物及其制备和应用,
中国，201610066031.6.

　　14. 白乃生，郭森, 刘庆超, 张云婷，张丽，白璐, 张鑫鑫，田潇. 一种大叶白蜡树种子化学成分标准化的提取物及其制备方法和应用,
中国，201610065908.X.

　　15. 白乃生,田潇，刘庆超, 郭森, 杨美琪,田梦琪,王天义,郭甜甜,李奉. 一种牡丹籽提取物及其作为抗肿瘤药物的应用,
中国，201710658187.8.

　　SELECTED PUBLICATIONS代表性论文

　　1. Lu Bai,a,‖ Qingchao Liu,a,‖ Yijing Cen, b* Jinping Huang, b Xinxin
Zhang, a Sen Guo, a Li Zhang,a Tiantian Guo, a Chi-Tang Ho, c and Naisheng Bai
a*(通讯作者). A New Sesquiterpene Lactone Glucoside and Other Constituents from
Inula salsoloides with Insecticidal Activities on Striped Flea Beetle
(Phyllotreta striolata Fabricius). Natural Product Research, 2017, DOI:
10.1080/14786419.2017.1329731 (In press). (SCI 4区Impact Factor 1.828)

　　2. Xiao Tian, Sen Guo, Kan He, Marc Roller, Meiqi Yang, Qingchao Liu, Li
Zhang, Chi-Tang Ho, and Naisheng Bai* . Characterization and quantitative
analysis of chemical constituents of Ptychopetalum olacoides Benth. (In press).
2017, DOI: 10.1080/14786419.2017.1354187 (SCI 4区Impact Factor 1.828)

　　3. Xiao Tian a, Meiqi Yang a, Sen Guo a, Qingchao Liu a, Li Zhang a, Chi-Tang Ho b,

　　NaishengBai a,* (通讯作者). Quantitative analysis and chemical fingerprint similarity for producing areas differentiation of the seeds of Paeonia suffruticosa Andr by HPLC. Chemical Research in Chinese Universities, 2017，33(4), 546―551. (SCI 4区Impact Factor 1.086)

　　4. Xueqin Cui,a Zhongxiao Ma,a Lu Bai,a Yong Wu, a Sen Guo,a Qingchao Liu,a Li Zhang,a Chi-Tang Ho,b Naisheng Baia,* (通讯作者).. Phytochemical analysis of Ziziphus jujuba leaves in six cultivars at the whole life stage by High Performance Liquid Chromatography. Chemical Research in Chinese Universities, 2017，doi: 10.1007/s40242-017-7076-z. (SCI 4区Impact Factor 1.086)

　　5. Lu Bai,a Xueqin Cui,a Ni Cheng,a Wei Cao,a Yong Wu,a Sen Guo,a Li Zhang,a Chi-Tang Ho,b and Naisheng Baia,* (通讯作者). Hepatoprotective standardized EtOH–water extract of the leaves of Ziziphus jujuba . Food & Function, 2016, 8, 816 – 822. (SCI 一区, Impact Factor 3.247)

　　6. Xueqin Cui , Jing Guo , Ching-Shu Lai , Min-Hsiung Pan, Zhongxiao Ma, Sen Guo , Qingchao Liu , Li Zhang , Chi-Tang Ho , Naisheng Bai a,* (通讯作者)。Analysis of bioactive constituents from the leaves of Amorpha fruticosa L. Journal of Food and Drug Analysis. 2016, DOI information: 10.1016/j.jfda.2016.10.006 (In press)。(SCI 4区Impact Factor 3.048)

　　7. Tian-Tian Guoa, Jian-Chun Zhangb, Hai Zhangc*, Qing-Chao Liu a, Yong Zhaoc, Yu-Fei Hou a, Lu Bai a, Li Zhang a, Xue-Qiang Liub, Xue-Ying Liud, Sheng-Yong Zhangd, and Nai-Sheng Baia* (通讯作者)。Bioactive spirans and other constituents from the leaves of Cannabis sativa f. sativa. Journal of Asian Natural Products Research。2017， 19(8)， 793-802. (SCI 4区Impact Factor 1.071)

　　8. Lu Bai, Sen Guo, Qingchao Liu, Xueqin Cui, Xinxin Zhang, Li Zhang, Xinwen Yang, Manwei Hou, Chi-Tang Ho, Naisheng Bai*(通讯作者)。Characterization of nine polyphenols in fruits of Malus pumila Mill by high-performance liquid chromatography. Journal of Food and Drug Analysis. 2016, 24(2), 293–298. (SCI 4区Impact Factor 3.048)

　　9. Lu Bai, Mi Jiang, Sen Guo, Qingchao Liu, Xinxin Zhang, Xiao Tian, Li Zhang, Chi-Tang Ho, Naisheng Bai*(通讯作者). Simultaneous Quantification of Six Sesquiterpene Lactones and a Flavonoid in the Whole Life Stage of Inula salsoloides by High Performance Liquid Chromatography。Analytical Methods. 2016, 8, 3587 – 3591. (SCI 3区Impact Factor 1.900)

　　10. Lu Bai, Hai Zhang, Qingchao Liu, Yong Zhao, Xueqin Cui, Sen Guo, Li Zhang, Chi-Tang Ho, and Naisheng Bai *(通讯作者).Chemical Characterization of the Main Bioactive Constituents from Fruits of Ziziphus jujube. Food & Function, 2016, 7, 2870 – 2877. (SCI 一区, Impact Factor 3.247)

　　11. Sen Guo, Tiantian Guo, Ni Cheng, Qingchao Liu, Yunting Zhang, Lu Bai, Li Zhang, Wei Cao, Chi-Tang Ho, and Naisheng Bai*(通讯作者). Hepatoprotective standardized EtOH-water extract from the seeds of Fraxinus rhynchophylla Hance. Journal of Traditional and Complementary Medicine. 2017，7, 158-164.

　　12. Tiantian Guo, Shaoping Wu, Sen Guo, Lu Bai, Qingchao Liu, and Naisheng Bai*(通讯作者). Synthesis and Evaluation of a Series of Oleanolic Acid Saponins as α-Glucosidase and α-Amylase Inhibitors. ARCHIV DER PHARMAZIE. 2015.348(9):615-628. (SCI 4区Impact Factor 2.043)

　　13. Sen Guo, Xueqin Cui, Mi Jiang, Lu Bai, Xiao Tian, Tiantian Guo, Qingchao Liu, Li Zhang, Chi-Tang Ho, Naisheng Bai*(通讯作者). Simultaneous characterization and quantification of seventeen main compounds in Rabdosia rubescens by high performance liquid chromatography. Journal of Food and Drug Analysis. 2017, 25，417-424. (SCI 4区Impact Factor 3.048)

　　14. Naisheng Bai; Kan He; Marc Roller; Ching-Shu Lai; Lu Bai; Min-Hsiung Pan.

　　Flavonolignans and Other Constituents from Lepidium meyenii with Activities in Anti-inflammation and Human Cancer Cell Lines. Journal of Agricultural and Food Chemistry. 2015, 63 (9): 2458–2463. (SCI一区Impact Factor 3.154)

　　15. Naisheng Bai, Kan He, Marc Roller, Ching-Shu Lai, Xi Shao, Min-Hsiung Pan, and Chi-Tang Ho. Secoiridoid Glucosides from Fraxinus excelsior with Effects on LPS-induced Nitrite Production in RAW 264.7 Macrophage and Human Cancer Cell Lines. (2013) American Chemical Society Symposium Series, “African Natural Plant Products Volume II: New Discoveries in Natural Products Chemistry, Health and Nutrition and Challenges in Botanical Standardization and Quality,” Edited by H.R. Juliani, J.E. Simon and C.T. Ho. Chapter 9, pp 115–125. (SCI)

　　16. Naisheng Bai, Kan He, Alvin Ibarra, Antoine Bily, Marc Roller, Xiaozhuo Chen and Ralph Ruhl. Iridoids from Fraxinus excelsior with Adipocyte Differentiation-Inhibitory and PPARα Activation Activity. Journal of Natural Products. 2010, 73, 2-6. (SCI二区，Impact Factor 3.159)

　　17. Bai, Naisheng; He, Kan; Zhou, Zhu; Tsai, Mei-Ling; Zhang, Li; Quan, Zheng; Shao, Xi; Pan, Min-Hsiung; Ho, Chi-Tang. Ent-Kaurane Diterpenoids from Rabdosia rubescens and Their Cytotoxic Effects on Human Cancer Cell Lines. Planta Medica 2010, 76, 140-145. (Impact Factor 1.85)

　　18. Bai, Naisheng; He, Kan; Zhou, Zhu; Tsai, Mei-Ling; Zhang, Li; Quan, Zheng; Shao, Xi; Pan, Min-Hsiung; Ho, Chi-Tang. Flavonoids from Rabdosia rubescens exert anti-inflammatory and growth inhibitory effect against human leukemia HL-60 cells. Food Chemistry 2010， 122， 831-835. (SCI二区，Impact Factor 3.146)

　　19. Naisheng Bai, Kan He, Marc Roller, Ching-Shu Lai, Xi Shao, Min-Hsiung Pan, and Chi-Tang Ho. Flavonoids and Phenolic Compounds from Rosmarinus officinalis L. and Their Effects on LPS-induced Nitrite Production in RAW 264.7 Macrophage and Human Cancer Cell Lines . Journal of Agricultural and Food Chemistry 2010. 58, 5363–5367. (SCI一区，Impact Factor 2.469)

　　20. Bai，Naisheng, He Kan, Roller Marc, Lai Ching-Shu, Shao Xi, Pan Min-Hsiung, Bily Antoine, Ho Chi-Tang, Flavonoid glycosides from Microtea debilis and their cytotoxic and anti-inflammatory effects, Fitoterapia (2011), 82 (2)， 168-172. (Impact Factor 1.363)

　　21. Bai, Naisheng; He, Kan; Roller, Marc; Zheng, Bolin; Chen, Xiaozhuo; Shao, Zhongguang; Peng, Tangsheng; Zheng, Qunyi. Active Compounds from Lagerstroemia speciosa, Insulin-like Glucose Uptake-Stimulatory/Inhibitory and Adipocyte Differentiation-Inhibitory Activities in 3T3-L1 Cells. Journal of Agricultural and Food Chemistry (2008), 56(24), 11668-11674. (SCI一区，Impact Factor 2.469)

　　22. Naisheng Bai, Ching-Shu Lai, Kan He, Zhu Zhou, Li Zhang, Zheng Quan, Nanqun Zhu, Qun Yi Zheng, Min-Hsiung Pan, and Chi-Tang Ho. (2006) Sesquiterpene Lactones from Inula britannica and Their Cytotoxic and Apoptotic Effects on Human Cancer Cell Lines. Journal of Natural Products. 69, 531-535. (SCI二区，Impact Factor 3.159)

　　23. Naisheng Bai, Zhou Zhu, Li Zhang, Nanqun Zhu, Shengmin Sang, and Ho, Chi-Tang Ho. (2005) Flavonoid Constituents from the Flower of Inula Britannica with Potential Antioxidative Activity. Journal of Food Lipids. 12, 141-149. (Impact Factor 1.07)

　　24. Naisheng Bai, Bing-Nan Zhou, Li Zhang, Kan He, and QunYi Zheng. Three new sesquiterpene lactones from Inula Britannica. In Oriental Foods and Herbs---Chemistry and Health Effects; Ho, C.T., Lin, J.K., and Zheng, Q.Y., Ed.; (2003) American Chemical Society Symposium Series, Washungton, DC, Vol. 859, Chapter 20, pp 271-278.

　　25. Yu Shao, Naisheng Bai and Bingnan Zhou. (1996) Kaurane Gluycosides from Inula britannica. Phytochemistry, 42, 783-786. (SCI二区，Impact Factor 3.104)

　　26. Bingnan Zhou, Naisheng Bai, Longze Lin and G.A. Cordell. (1994) Sesquiterpene lactones from Inula soloides. Phytochemistry, 36, 721-724. (SCI二区，Impact Factor 3.104)

　　27. Bing-nan Zhou, Nai-sheng Bai, Long-ze Lin and G.A. Cordell. (1993) Sesquiterpene lactones from Inula britannica. Phytochemistry, 34, 249-252. (SCI二区，Impact Factor 3.104)

　　OTHER PUBLICATIONS & PRESENTATIONS其它论文

　　28. Alvin Ibarra, Naisheng Bai, Kan He, Antoine Bily, Julien Cases, Marc Roller, Shengmin Sang. Fraxinus excelsior seed extract FraxiPure(tm) limits weight gains and hyperglycemia in high-fat diet-induced obese mice. Phytomedicine. (2010), 18(6)，479-485。 (Impact Factor 2.174)

　　29. Alvin Ibarra, Julien Cases, Antoine Bily, Kan He, Naisheng Bai, Marc Roller, Aurélie Coussaert, Christophe Ripoll. Importance of Extract Standardization and In Vitro/Ex Vivo Assay Selection for the Evaluation of Antioxidant Activity of Botanicals: A Case Study on Three Rosmarinus officinalis L. Extracts. Journal of Medicinal Food. (2010)， 13(5)， 1167-1175. (Impact Factor 1.39)

　　30. Ibarra, Alvin; He, Kan; Bai, Naisheng; Bily, Antoine; Roller, Marc; Coussaert, Aurelie; Provost, Nicolas; Ripoll, Christophe. Fenugreek extract rich in 4-hydroxyisoleucine and trigonelline activates PPAR and inhibits LDL oxidation: key mechanisms in controlling the metabolic syndrome. Natural Product Communications

获奖情况

　　在药用植物化学成分的提取分离、结构鉴定及其生物活性研究方面成果丰硕，特别是在抗癌药物研究和降血糖、肝损伤保护药物研究和植物健康品领域多有发现。曾先后对植物 Paeonia suffruticosa 牡丹籽， Ziziphus jujuba Mill. 红枣， Cannabis sativa f. sativa. 汉麻叶， Inula britannica 旋复花, Inula salsoloides 沙旋复花, Rosmarinus officinalisL. 迷迭香, Lepidium meyenii Walpers 玛卡, Microtea debilis 和 Rabdosia rubescens 冬凌草 等中的抗炎、抗肿瘤有效成分，植物 Lagerstroemia speciosa， Fraxinus rhynchophylla Hance 白蜡种子和 Fraxinus excelsior 等中的降血糖有效成分进行了系统的研究。植物 Morus australis Poir 鸡桑根， Ziziphus jujuba Mill. 红枣叶，Rabdosia rubescens 冬凌草，和 Fraxinus rhynchophylla Hance 白蜡种子等中的保肝活性有效成分进行了系统的研究。 也包括多种草药和植物的工艺过程和分析方法的产品开发研究。有7 项成果获得美国和国际专利20项。有8 项成果申请中国发明专利，授权1项。发表研究论文50 多篇, 包括SCI学术刊物论文40多篇，其中大部分发表在该领域的顶级期刊例如 Food and Function,， Journal of Natural Products, Planta Medica, Journal of Agricultural and Food Chemistry, and Phytochemistry。有5篇以第一或通讯作者发表在SCI一区顶级期刊上。