所属部门：食品科学与工程学院

职务/职称：教授（三级）

荣誉：博士生导师；中国食品科学技术学会会员，中国化工学会会员；曾任陕西省化工学会常务理事，陕西省化工学会工业催化专业委员会副主任委员。

电子邮件：xlzhang@nwu.edu.cn

个人简介

一、学习经历：2002年7月浙江大学生物化工专业毕业, 获工学博士学位； 1991年7月西北大学化学工程专业毕业, 获工学硕士学位；1983年7月西北大学基本有机合成专业毕业，获工学学士学位；曾先后公派赴日本名古屋大学留学或访问研究。

二、工作经历：1983年7月本科毕业留校西北大学化工系（学院）任教，从事化学工程和生物化工专业教学及科研工作，历任讲师、副教授、教授职称，曾担任生物化工教研室主任、西北大学化工系主任等职；指导生物化工、化学工程、工业催化专业硕士、博士研究生；2018年转任西北大学食品科学与工程学院，指导生物资源化学与利用专业博士、硕士研究生。

先后主讲本科《化学反应工程》、《生物反应工程》、《酶工程》、《工业催化》、《食品工厂设计》，研究生《发酵与细胞培养》、《生物催化过程》、《生物催化理论与技术》、《食品酶工程》等课程。发表研究论文140余篇，其中40余篇被SCI、EI收录；授权发明专利11件；成果转化应用解决企业技术难题3项。

研究方向：发酵与酶工程、催化反应工程、新资源食品及食品添加剂

研究成果

一、 主持科研项目

先后主持国家自然科学基金高技术探索项目《重组酵母高密度发酵条件优化及基因表达规律的研究》（29886001）、陕西省重点研发计划项目《磷脂酶D的分子改造及高性能酶制备技术研究》（2018NY-131）、横向合作项目《可再生资源蓖麻油制备癸二酸清洁生产示范技术开发》等13项科研项目。

二、 代表性学术论文

1. Li, Y.; Zhang, X.; Gao, S.; Guo, W.; Liu, Z.; Wu, L.; Zheng, L.; Ding, X.; Yan, H.; Wang, Y., Synthesis of the CeO2 Support with a Honeycomb-Lantern-like Structure and Its Application in Dry Reforming of Methane Based on the Surface Spatial Confinement Strategy. The Journal of Physical Chemistry C 2023, 127 (2), 1032-1048.

2. Li, H.; Zhang, T.; Tang, K.; Li, B.; Zhang, X.; Zhao, B.; Wang, J., Preparation of hyperbranched 4-dimethylaminopyridine catalyst for the efficient synthesis of vitamin E succinate. C. R. Chim. 2023, 26, 11-22.

3. Zhang, T.; Li, B.; Li, H.; Liu, Y.; Li, J.; Zhao, B.; Zhang, X.; Wang, J., The efficient and green synthesis of biodiesel from crude oil without degumming catalyzed by sodium carbonate supported MoS2. RSC Adv. 2022, 12, 24456-24464.

4.  Qi, X.; Li, B.; Omarini, A. B.; Gand, M.; Zhang, X.; Wang, J., Discovery of TCMs and derivatives against the main protease of SARS-CoV-2 via high throughput screening, ADMET analysis, and inhibition assay in vitro. Journal of Molecular Structure 2022, 1268, 133709.

5. Li, Y.; Wang, Y.; Zhang, X.; Ding, X.; Liu, Z.; Zhu, R.; Wu, L.; Zheng, L., Ni supported on natural clay of palygorskite as catalyst for dry reforming of methane: Thermodynamic analysis and impacts of preparation methods. Int. J. Hydrogen Energy 2022, 47, 20851-20866.

6. Wang, J.; Qi, X.; Yu, W.; Zhang, X.; Zhang, T.; Li, B., Highly efficient biosynthesis of phosphatidylserine by the surface adsorption-catalysis in purely aqueous media and mechanism study by biomolecular simulation. Molecular Catalysis 2021, 502, 111397.

7. Zhang, T.; Li, B.; Zhang, X.; Wang, J.; Wei, L.; Zhao, B.; Li, B., 4-Dimethylaminopyridine grafted on MCM-41 as an efficient and highly stable catalyst for the production of α-tocopherol acetate. J. Porous Mat. 2020, 27 (6), 1639-1648.

8. Wei, L. H.; Li, B. L.; Zhang, X. L.; Tang, K.; Zheng, W. W.; Chen, D.; Zhao, B. X., Choline derivatives immobilized on silica to catalyze transesterification reaction for production of glycerophosphocholine. Turk. J. Chem. 2020, 44 (1), 249-260.

9. Wang, J.; Zhang, X.; Omarini, A. B.; Li, B., Virtual screening for functional foods against the main protease of SARS-CoV-2. Journal of Food Biochemistry 2020, 44 (11), e13481.

10. Wang, J.; Yu, W.; Zhang, X.; Zhang, T.; Wang, H.; Shu, W.; Liu, L.; Zhao, B.; Li, B., Two-step modification of silica for efficient adsorption of phosphatidylcholine in water and application in phospholipase D-catalyzed transphosphatidylation. Biotechnology Progress 2020, 36 (3), e2949.

11. Sun, W.; Fu, Z.; Shi, H.; Jin, C.; Liu, E.; Zhang, X.; Fan, J., Cu3P and Ni2P co-modified g-C3N4 nanosheet with excellent photocatalytic H2 evolution activities. Journal of Chemical Technology & Biotechnology 2020, 95 (12), 3117-3125.

12. Qi, X. Y.; Zheng, W. W.; Zhang, X. L.; Wei, L. H.; Tang, K.; Zhao, B. X.; Li, B. L., Effective synthesis of menthol derivative monomenthyl succinate catalyzed by nanoscale silicon dioxide immobilized DMAP derivative in mixed solvent system. Comptes Rendus Chimie 2020, 23 (6-7), 375-384.

13. Liu, L.; Zhang, T. T.; Zhang, X. L.; Wang, J.; Shu, W. F.; Qi, X. Y.; Zhao, B. X.; Li, B. L., An efficient method for determination of components in docosahexaenoic acid-phosphatidylcholine using pre-column derivatization HPLC. Rev Roum Chim 2020, 65 (10), 955-962.

14. 段丹丹; 李冰麟; 张小里; 王姣; 于文宇; 王焕; 赵彬侠, 水-固相磷脂酶D催化反应体系合成磷脂酰甘油. 化学工程 2019, 47 (05), 1-5+17.

15. 陈丹; 张小里; 李冰麟; 卫龙辉; 赵彬侠; 张耀中, 正己烷/丙酮混合溶剂中非均相催化合成α-生育酚琥珀酸酯. 化工进展 2019, 38 (09), 4095-4101.

16. Wang, J.; Yu, W.; Zhang, X.; Zhang, T.; Wang, H.; Shu, W.; Liu, L.; Zhao, B.; Li, B., Two-step modification of silica for efficient adsorption of phosphatidylcholine in water and application in phospholipase D-catalyzed transphosphatidylation. Biotechnology Progress 2019, e2949-e2949.

17. Wang, J.; Li, B. L.; Zhang, X. L.; Hu, Q. J.; Yu, W. Y.; Wang, H.; Duan, D. D.; Li, J.; Zhao, B. X., Docking and molecular dynamics studies on the mechanism of phospholipase D-mediated transphosphatidylation to construct the reaction kinetic model: Application in phosphatidylserine production. Journal of the Taiwan Institute of Chemical Engineers 2019, 96, 82-92.

18. Sun, W. J.; Jia, J.; Jin, C. Y.; Zhang, X. L.; Liu, E. Z.; Fan, J., In situ synthesis of Cu3P/g-C3N4 heterojunction with superior photocatalytic hydrogen evolution. Journal of Physics D-Applied Physics 2019, 52 (46).

19. Li, B. L.; Wang, J.; Li, H. Y.; Zhang, X. L.; Duan, D. D.; Yu, W. Y.; Zhao, B. X., Efficient and green aqueous-solid system for transphosphatidylation to produce phosphatidylhydroxybutyrate: Potential drugs for central nervous system's diseases. Biotechnology Progress 2019, 35 (1).

20. Li, B.; Wang, J.; Li, J.; Zhang, X.; Yu, W.; Wang, H.; Duan, D.; Zhao, B., A comparison between continuous and batch processes to produce phosphatidylserine in the efficient and green aqueous-solid system. Biotechnology Progress 2019, 35 (3), e2777.

21. Li, B.; Li, H.; Zhang, X.; Fan, P.; Liu, L.; Li, B.; Dong, W.; Zhao, B., Calcined sodium silicate as an efficient and benign heterogeneous catalyst for the transesterification of natural lecithin to L-α-glycerophosphocholine. Green Processing and Synthesis 2019, 8 (1), 78-84.

22. Chen, D.; Li, B.; Li, B.; Zhang, X.; Wei, L.; Zheng, W., Synthesis of vitamin E succinate catalyzed by nano-SiO2 immobilized DMAP derivative in mixed solvent system. Green Processing and Synthesis 2019, 8 (1), 667-676.

23. 李环宇; 李冰麟; 王姣; 段丹丹; 张小里; 赵彬侠, 非天然磷脂化合物磷脂酰基γ-羟基丁酸的合成. 化工进展 2018, 37 (10), 4029-4032.

24. Li, B. L.; Duan, D. D.; Wang, J.; Li, H. Y.; Zhang, X. L.; Zhao, B. X., Improving phospholipase D activity and selectivity by bio-imprinting-immobilization to produce phosphatidylglycerol. J Biotechnol 2018, 281, 67-73.

25. Li, B.; Chen, D.; Zhang, X. L.; Dong, W. B.; Zhao, B. X., A convenient method to immobilize 4-dimethylaminopyridine on silica gel as a heterogeneous nucleophilic catalyst for acylation. Chem. Pap. 2018, 72 (6), 1339-1345.

26. 邓杨敏; 李冰麟; 董文博; 杨开利; 张小里; 赵彬侠, 磷脂酰乙醇胺的酶促合成及底物抑制动力学. 化工进展 2017,  (07), 2601-2606.

27. Zhang, X.; Li, B.; Wang, J.; Li, H.; Zhao, B., High-Yield and Sustainable Production of Phosphatidylserine in Purely Aqueous Solutions via Adsorption of Phosphatidylcholine on Triton-X-100-Modified Silica. J Agr Food Chem 2017, 65 (49), 10767-10774.

28. 杨兰兰; 张小里; 封娟娟; 朱南南; 赵彬侠, 磷脂酶D高产菌株的原生质体紫外诱变选育. 生物加工过程 2016,  (02), 22-26.

29. 任方旭; 孙全莲; 董文博; 张小里; 赵彬侠, 发酵液中鼠李糖脂的活性炭吸附-酸沉淀分离. 化学工程 2016,  (07), 15-18.

30. 封娟娟; 朱南南; 邓杨敏; 韩晓玲; 张小里; 赵彬侠, 反复分批式反应提高磷脂酰丝氨酸的生产能力. 化工进展 2016,  (04), 1180-1183.

31. 陈庆; 张小里; 王建雄, 氨基膦酸螯合树脂吸附癸二酸中铁离子的研究. 化学工程 2016,  (03), 26-29+45.

32. Li, H.-Y.; Zhang, X.-L.; Yan, B.; Zhao, B.-X.; Gao, J., Preparation and catalytic performance of quaternary ammonium base resin for methanolysis of natural phosphatidylcholine. Chem. Pap. 2016, 70 (6), 706-712.

33. Li, B. L.; Wang, J.; Zhang, X. L.; Zhao, B. X.; Niu, L., Aqueous-Solid System for Highly Efficient and Environmentally Friendly Transphosphatidylation Catalyzed by Phospholipase D To Produce Phosphatidylserine. J Agr Food Chem 2016, 64 (40), 7555-7560.

34. Li, B. L.; Wang, J.; Zhang, X. L.; Zhao, B. X., An Enzyme Net Coating the Surface of Nanoparticles: A Simple and Efficient Method for the Immobilization of Phospholipase D. Ind Eng Chem Res 2016, 55 (40), 10555-10565.

35. Zhang, Y.; Zhou, J.; Han, X.; Zhang, X.; Hu, J., Kinetics behavior of long-chain n-alkanethiols adsorbed on copper surface. Applied Surface Science 2015, 353, 979-985.

36. Zhang, Y.; Zhou, J.; Zhang, X.; Hu, J.; Gao, H., Solvent polarity effect on quality of n-octadecanethiol self-assembled monolayers on copper and oxidized copper. Applied Surface Science 2014, 320 (0), 200-206.

37. Li, H.-Y.; Zhang, X.-L.; Zhang, J.-B.; Zhang, T.-T.; Zhao, B.-X., Preparing L-α-Glycerophosphocholine in a Phase-Transfer Catalytic Reaction: Kinetic Study. Int J Chem Kinet 2014, 46 (3), 169-175.

38. 王端好; 张小里, 山梨醇脱氢酶性质研究. 生物技术 2013,  (01), 70-73.

39. Zhang, T.; Zhang, X.; Li, H.; Bai, W.; Zhao, B., Kinetic evaluation of the ethanolysis of phosphatidylcholine catalyzed by choline hydroxide. Reac Kinet Mech Cat 2013, 110 (1), 31-39.

40. Li, H.; Zhang, X.; Bai, W.; Zhang, J.; Zhang, T.; Zhao, B., Study on the preparation of l-α-glycerophosphocholine catalyzed by low boiling point organic amines. Reac Kinet Mech Cat 2013, 108 (2), 305-316.

41. 章结兵; 张小里; 李红亚; 赵彬侠, 固定床动力学模型在离子交换过程中的应用. 化学工程 2012,  (05), 54-56+69.

42. 张甜甜; 张小里; 李红亚; 豆坤坤; 王彦雄, 大豆磷脂制备甘油磷脂酰胆碱均相催化反应研究. 应用化工 2012,  (04), 599-601.

43. 王彦雄; 张小里; 李红亚; 豆坤坤; 张甜甜; 姚娜, 蓖麻油催化裂解制备癸二酸的清洁工艺研究. 工业催化 2012,  (04), 68-71.

44. 刘媛媛; 张小里; 姚娜; 李红亚; 赵彬侠, 磷脂酶D的紫外诱变选育及发酵条件的优化. 化工进展 2012,  (09) , 2036-2038+2063.

45. Zhang, J.; Zhang, X. L.; Li, H.; Zhao, B., Ion Exchange Adsorption Studies of Miglitol in a Fixed Bed. Chem Eng Technol 2012, 35 (5), 811-818.

46. Li, H.; Zhang, X.; Zhang, T.; Dou, K.; Zhao, B., Study on the methanolysis of natural lecithin catalyzed by quaternary ammonium base resin. Reac Kinet Mech Cat 2012, 107 (2), 345-354.

47. 章结兵; 张小里; 李红亚; 赵彬侠; 熊柱, 米格列醇在大孔D001树脂上的离子交换性研究. 化学工程 2011,  (08).

48. Jia, Z.; Zhang, X.; Cao, X.; Liu, J.; Qin, B., Production of lovastatin by a self-resistant mutant of Aspergillus terreus. Ann Microbiol 2011, 61 (3), 615-621.

49. Jia, Z. H.; Zhang, X. L.; Zhao, Y. L.; Cao, X. J., Enhancement of Lovastatin Production by Supplementing Polyketide Antibiotics to the Submerged Culture of Aspergillus terreus. Appl Biochem Biotech 2010, 160 (7), 2014-2025.

50. 张耀中; 赵彬侠; 张小里; 刘林学; 章毅; 曹昕; 路程, Fe₂O₃/SiO₂对异辛醇氧化生成异辛酸反应的催化性能研究. 分子催化 2009,  (06), 529-533.

51. 王端好; 赵彭花; 薛小波; 蒋德富; 张小里, 甘油诱导氧化葡萄糖酸杆菌山梨醇脱氢酶. 精细化工 2009,  (01), 18-20.

52. 王端好; 薛小波; 张小里, 氧化葡萄糖酸杆菌的选育及其发酵条件优化. 西北大学学报(自然科学版) 2009,  (02), 237-240.

53. 王端好; 孙蓓; 赵彭花; 薛小波; 张小里, 化学生物组合法合成米格列醇及其表征. 化工进展 2009,  (03), 477-480.

54. Jia, Z. H.; Zhang, X. L.; Zhao, Y. L.; Cao, X. J., Effects of divalent metal cations on lovastatin biosynthesis from Aspergillus terreus in chemically defined medium. World J Microb Biot 2009, 25 (7), 1235-1241.

55. Jia, Z. H.; Zhang, X. L.; Cao, X. J., Effects of carbon sources on fungal morphology and lovastatin biosynthesis by submerged cultivation of Aspergillus terreus. Asia-Pac J Chem Eng 2009, 4 (5), 672-677.

56. 贾志华; 张小里; 曹学君, 碳源对土曲霉中洛伐他汀生物合成的影响. 化学工程 2008,  (05), 51-54.

57. 王端好; 张小里, 氧化葡萄糖酸杆菌培养及生物转化性能的研究. 食品科学 2007,  (10), 332-335.

58. Zhang, X. L.; Xia, Z. J.; Zhao, B. X.; Cen, P. L., Enhancement of plasmid stability and protein productivity using multi-pulse, fed-batch culture of recombinant Saccharomyces cerevisiae. Biotechnol Lett 2002, 24 (12), 995-998.

59. Zhang, X. L.; Ito, T.; Kondo, K.; Kobayashi, T.; Honda, H., Production of single chain recombinant monellin by high cell density culture of genetically engineered Candida utilis using limited feeding of sodium ions. J Chem Eng Jpn 2002, 35 (7), 654-659.

60. 张小里; 夏诏杰; 刘颖; 赵彬侠; 郑晓钢; 熊朝晖, 营养物及补料方式对重组酵母产α-淀粉酶的影响. 高校化学工程学报 2001,  (02), 144-148.

61. Zhang, X. L.; Xia, Z. J.; Zhao, B. X.; Cen, P. L., Enhancement of production of cloned alpha-amylase by lactic acid feeding from recombinant Saccharomyces cerevisiae using a SUC2 promoter. Biotechnol Lett 2001, 23 (4), 259-262.

62. 张小里; 赵彬侠; 马政生; 熊朝晖, 氮源对酵母工程菌株生产α-淀粉酶的影响. 化学工程 2000,  (06), 31-33+3.

63. 张小里; 赵彬侠; 陈五岭; 陈开勋; 陈志昕; 郭生武, 硫酸盐还原菌腐蚀石油管材的限制因素研究. 现代化工 2000,  (03), 29-31+33.

64. 张小里; 陈志昕; 刘海洪; 郭生武; 陈开勋, 环境因素对硫酸盐还原菌生长的影响. 中国腐蚀与防护学报 2000,  (04), 224-229.

65. 张小里; 赵彬侠; 陈五岭; 岑沛霖, 生物转化法生产果糖1,6-二磷酸反应条件优化. 化学工程 1998,  (06), 29-31.

66. 张小里; 岑沛霖, 伴有辅酶再生的多酶反应技术进展. 化工进展 1996,  (06), 50-52+59.

67. Ohshima, T.; Zhang, X. L.; Iijima, S.; Kobayashi, T.; Hishinuma, F., Control of Gene-Expression from the Suc 2 Promoter of Saccharomyces-Cerevisiae Using 2 Carbon-Sources. Kagaku Kogaku Ronbun 1992, 18 (5), 693-700.

68. Ohshima, T.; Kawase, Y.; Zhang, X. L.; Iijima, S.; Kobayashi, T.; Murooka, Y. H., On-Off Control of Gene-Expression from Lambda-Phage Prpl Promoter in High-Concentration Cultivation of Gene-Engineered Escherichia-Coli. Kagaku Kogaku Ronbun 1992, 18 (5), 684-692.

69. 张蕴璧; 阎桂藩; 赫修德; 叶良勋; 张小里, 流化床电极的研究及其应用. 化学工程 1986,  (06), 45-51.

三、 主要专利

[1] 一种枝化型高固载4-二甲氨基吡啶催化剂及其制备方法，ZL202010491322.6

[2] 一种复合改性蒙脱土吸附剂、制备方法及其应用，ZL202010619991.7

[3] 一种生产磷脂酰基γ-羟基丁酸的方法，CN201810349629.5

[4] 一种提高磷脂酰甘油合成反应活力的磷脂酶D固定化方法，ZL201710092814.6

[5] 一种负载化4-(N,N-二甲基)氨基吡啶催化剂的制备方法，ZL201710004539.8

[6] 一种天然L-α-甘油磷脂酰胆碱的制备方法，ZL201210513309.1

[7] 一种蓖麻油类化合物裂解制备癸二酸的方法，ZL201310597679.2

[8] 一种天然L-α-甘油磷脂酰胆碱及其制备方法，ZL201110349727.7

获奖情况

[1] 陕西省第四届研究生创新成果展，一等奖（导师），新资源食品磷脂酰丝氨酸无污染连续生产

[1] 陕西陕化煤化工集团有限公司, 尿素合成CO2压缩系统微生物腐蚀研究

[2] 陕西高等学校科学技术奖励, 二等奖，含铜废水流化床电沉积处理