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　　个人简介

颜敏，女，汉族，分析化学博士。西北大学食品学院讲师，硕士生导师。 本科毕业于南京大学化学化工学院，博士毕业于中国科学院大连化学物理研究所。主持国家自然科学基金1项，陕西省科技计划项目1项，参与了多项国家及省部级项目。目前已经在《Metabolism-clinical and experimental》、《Food chemistry》、《Analytical chemical acta》、《Food research international》、《Food bioscience》、《色谱》等期刊发表论文。

研究方向：

1.      食品功能代谢组学研究

2.      液相色谱-质谱和气相色谱-质谱联用技术新方法研究

主持项目：

1. 国家自然科学基金青年项目，32202065，基于动态代谢组学的苹果多酚调控肠道菌群改善肝脏脂代谢作用机制研究

2. 陕西省科学技术发展计划，2020JQ-581，基于代谢组学的小鼠邻苯二甲酸二丁酯暴露应答机制研究

发表论文情况：

1.    Yan, M.; Qi, H.; Xia, T.; Zhao, X.; Wang, W.; Wang, Z.; Lu, C.; Ning, Z.; Chen, H.; Li, T.; Tekcham, D. S.; Liu, X.; Liu, J.; Chen, D.; Liu, X.; Xu, G.; Piao, H.-l., Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPKα. Metabolism-Clinical and Experimental 2019, 91, 18-29.

2.    Yan, M.; Hu, J.; Wang, L.; Zhang, T.; Xiao, Z.; Yuan, Y.; Yue, T., Metabolic profiling of abdominal subcutaneous adipose tissue reveals effects of apple polyphenols for reversing high-fat diet induced obesity in C57BL/6 J mice. Food Chemistry 2025, 473.

3.    Yan, M.; Xu, G., Current and future perspectives of functional metabolomics in disease studies-A review. Analytica Chimica Acta 2018, 1037, 41-54.

4.    Yan, M.; Qi, H.; Li, J.; Ye, G.; Shao, Y.; Li, T.; Liu, J.; Piao, H.-L.; Xu, G., Identification of SPOP related metabolic pathways in prostate cancer. Oncotarget 2017, 8 (61), 103032-103046.

5.    Zhang, T.; Yan, M.（共同一作）; Hou, X.; Chang, M.; Song, W.; Yue, T., Identification of mouse metabolic variations related to patulin-induced acute and subacute hepatotoxicity by ultra-high-performance liquid chromatography high-resolution mass spectrometry. Food Research International 2023, 166.

6.  Wang, F.; Yan, M. （共同一作）; Zhang, T.; Tian, Z.; Niu, X.; Guo, Z.; Wang, X.; Li, X.; Song, W.; Luo, Y. e.; Yuan, Y.; Yue, T., Insight into sodium selenite-induced metabolic reprogramming in response to main seleno-amino acid enrichment in Saccharomyces cerevisiae using metabolomics. Food Bioscience 2024, 59.

7.    颜敏; 刘静; 夏天; 许国旺; 朴海龙, 细胞蛋白质组学和代谢组学整合策略表征散斑型BTB/POZ蛋白质突变调控的关键代谢通路. 色谱 2019, 37 (08), 887-896.

8.    Zhang, T.; Yan, M.; Chang, M.; Hou, X.; Wang, F.; Song, W.; Wang, Y.; Feng, K.; Yuan, Y.; Yue, T., Integrated transcriptomics and metabolomics reveal the mechanism of intestinal damage upon acute patulin exposure in mice. Ecotoxicology and Environmental Safety 2024, 276.

9.    Zhang, T.; Chang, M.; Hou, X.; Yan, M.; Zhang, S.; Song, W.; Sheng, Q.; Yuan, Y.; Yue, T., Apple polyphenols prevent patulin-induced intestinal damage by modulating the gut microbiota and metabolism of the gut-liver axis. Food Chemistry 2025, 463.

10.  Wang, F.; Li, X.; Wang, X.; Kurtovic, I.; Yan, M.; Wei, J.; Zhang, T.; Zeng, X.; Yuan, Y.; Yue, T., Accumulation and metabolism of selenium in the rare yeast Kazachstania unispora during the selenium enrichment process. Food Chemistry 2024, 459.

11.  Wang, W.; Tekcham, D. S.; Yan, M.; Wang, Z.; Qi, H.; Liu, X.; Piao, H.-L., Biochemical reactions in metabolite-protein interaction. Chinese Chemical Letters 2018, 29 (5), 645-647.

12.  Zhang, T.; Chang, M.; Zhou, Y.; Wang, M.; Yan, M.; Hou, X.; Liu, R.; Yuan, Y.; Yue, T., Dynamic alterations of flavor, functional nutrients, and microbial community during fermentation of different animal milk kefirs. Food Research International 2024, 186.

13.  Ren, S.; Shao, Y.; Zhao, X.; Hong, C. S.; Wang, F.; Lu, X.; Li, J.; Ye, G.; Yan, M.; Zhuang, Z.; Xu, C.; Xu, G.; Sun, Y., Integration of Metabolomics and Transcriptomics Reveals Major Metabolic Pathways and Potential Biomarker Involved in Prostate Cancer. Molecular & Cellular Proteomics 2016, 15 (1), 154-163.

14.  Li, J.; Ren, S.; Piao, H.-l.; Wang, F.; Yin, P.; Xu, C.; Lu, X.; Ye, G.; Shao, Y.; Yan, M.; Zhao, X.; Sun, Y.; Xu, G., Integration of lipidomics and transcriptomics unravels aberrant lipid metabolism and defines cholesteryl oleate as potential biomarker of prostate cancer. Scientific Reports 2016, 6.

15.  孙海超; 朴海龙; 齐欢; 颜敏; 刘宏旭, 基于代谢组学的多西他赛调控肺癌细胞代谢重编程研究. 中国肺癌杂志 2019, 22 (04), 208-215.

16.  Zeng, J.; Kuang, H.; Hu, C.; Shi, X.; Yan, M.; Xu, L.; Wang, L.; Xu, C.; Xu, G., Effect of Bisphenol A on Rat Metabolic Profiling Studied by Using Capillary Electrophoresis Time-of-Flight Mass Spectrometry. Environmental Science & Technology 2013, 47 (13), 7457-7465.

参编著作：

1.    Yue, T.; Sheng, Q.; Luo, Y.; Xiao, Z.; Wang, Y.; Song, W.; Yan, M.; Niu, H.; Zhang, T.; Li, N., Biflavonoids and Oligomeric Flavonoids from Food. In Handbook of Dietary Phytochemicals, Xiao, J.; Sarker, S. D.; Asakawa, Y., Eds. Springer Singapore: Singapore, 2020; pp 1-49.