所属部门：食品科学与工程学院

姓    名：刘玉霞

职    称：讲师

电子邮箱：yuxialiu@nwu.edu.cn

个人简介：

刘玉霞，中共党员，博士后，硕士生导师。研究方向为营养糖生物学和糖工程，具体包括：功能性低聚糖的制备、分析、结构解析及结构与功能关系研究；糖芯片构建新方法的开发、天然寡糖芯片构建及其应用研究；天然多糖可控降解、修饰及其结构与功能关系研究。先后在Carbohydrate Polymers、npj Biofilms and Microbiomes、Analytical Chemistry、Journal of Agricultural and Food Chemistry、Food Chemistry、Journal of Biological Macromolecules、Catalysis Science & Technology、Chemistry-A European Journal等国际学术期刊发表SCI论文20余篇，其中第一作者8篇，通讯作者5篇，授权发明专利3项。主持国家自然科学基金青年项目1项，主持中国博士后基金面上项目1项，主持陕西基础科学（化学、生物学）研究院青年项目1项，参与国家自然科学基金面上项目3项，参与陕西省科技创新团队等项目2项。目前任Asian Journal of Organic Chemistry审稿人。

研究方向：

1. 营养糖生物学和糖工程

2. 食源性寡糖芯片构建及其应用研究

3. 食源性多糖可控降解、修饰及其结构与功能关系研究

科研项目：

[1] 双功能手性双核铜催化四氢异喹啉的需氧不对称交叉脱氢偶联反应研究，21902126，国家自然科学基金青年项目，2019年8月，主持。

[2] 黏蛋白型O-糖芯片构建及幽门螺旋杆菌结合糖链筛选研究，2019M663947XB，中国博士后面上项目，2019年11月，主持。

[3] 陕西基础科学（化学、生物学）研究院基础科学研究计划青年项目，黏蛋白O-糖链芯片的构建及其在鼠伤寒沙门氏菌粘附受体靶点筛选中的应用，23JHQ040，2024年5月，主持。

[4] 陕西省科学技术厅创新人才推进计划-科技创新团队，2020TD-044，糖生物学与糖工程创新团队，2020年6月，参与。

[5] 陕西省科技厅，陕西省2021年自然科学基础研究计划项目，2021JQ-448，温热增效作用下的等离子体技术灭活脂环酸芽孢杆菌芽孢机制研究，2021年1月，参与。

科研论文:

（1）Liu, Yuxia; Wei, Ming; Li, Zhao, Guo; Yilong; Yan, Xiuzhen; Wang, Shukai; Song, Xuezheng; Wang, Zhongfu*; Huang, Linjuan*. Isolation, structural characterization of natural chondroitin sulfate oligosaccharides and their binding study with anti-angiogenic factors, Carbohydrate Polymers, 2025, 353: 123262. (SCI一区top)

（2）Zhao, Yilong; Chen, Min; Li, Guo; Zhang, Lan; Duan, Yuxi; Zhong, Peiyun; Yang, Tong; Yao, Yuxuan; Wang, Yizhe; Gong, Guiping; Huang, Linjuan; Liu, Yuxia*; Wang, Zhongfu*. Antioxidant activity of differently sized and sulfated konjac glucomannan fragments prepared by the relay strategy. International Journal of Biological Macromolecules, 2025, 307, 142188. (SCI二区top)

（3）Li, Cheng; Chen, Qinghui; Rong, Jinqiao; He, Houde; Lu, Yu; Liu, Yuxia*; Zhongfu Wang*. LC-MS characterization of N/O-glycans of α- and β-subunits of Chicken ovomucin separated by SDS-PAGE. Analytical Biochemistry, 2024, 694: 115625. (SCI四区)

（4）Liu, Yuxia; Yang, Tong; Rong, Jinqiao; Yuan, Jinhang; Fan, Jiangbo; Man, Lijuan; Wei, Ming; Lan Yao; Liu, Yinchuan; Gong Guiping; Lu Yu; Song, Xuezheng; Huang, Linjuan*; Wang, Zhongfu*. Integrated analysis of natural glycans using a versatile pyrazolone-type heterobifunctional tag ANPMP. Carbohydrate Polymers, 2023, 327: 121617. (SCI一区top)

（5）Liu, Yuxia*; Yan, Yonggang; Xue, Dong; Wang, Zhongfu; Xiao, Jianliang; Wang, Chao*. Highly efficient binuclear copper-catalyzed oxidation of N,N-Dimethylanilines with O₂. ChemCatChem, 2020, 12(8): 2221-2225. (SCI三区)

（6）Liu, Yuxia*; Wang, Chao; Huang, Linjuan; Xue, Dong*. Room-temperature Palladium(II)-catalyzed direct 2-arylation of indoles with tetraarylstannanes. Synlett, 2020, 31(16): 1613-1618. (SCI四区)

（7）Liu, Yuxia; Xue, Dong; Li, Chaoqun; Xiao, Jianliang; Wang, Chao*. Reactions catalyzed by a binuclear copper complex: selective oxidation of alkenes to carbonyls with O₂. Catalysis Science & Technology, 2017, 7(23): 5510-5514. (SCI二区)

（8）Liu, Yuxia; Wang, Chao*; Xue, Dong; Xiao, Miao; Li, Chaoqun; Xiao, Jianliang*. Binuclear copper complex catalysed reactions: aerobic cross dehydrogenative coupling of N-aryltetrahydroisoquinolines. Chemistry-A European Journal, 2017, 23(13): 3051-3061. (SCI二区top)

（9）Liu, Yuxia; Wang, Chao*; Xue, Dong; Xiao, Miao; Liu, Jiao; Li, Chaoqun; Xiao, Jianliang*. Binuclear copper complex catalysed reactions: relay aerobic oxidation of N-aryltetrahydroisoquinolines to dihydroisoquinolones with a VB1 analogue. Chemistry-A European Journal, 2017, 23(13): 3062-3066. (SCI二区top, 内封面)

（10）Zou, Meiyi; Liu, Yuxia; Man, Lijuan; Lan, Yao; Wei, Qian; Jin, Wanjun; Chen, Qinghui; Jia, Yue; Yao, Xinbo; Lu, Yu; Huang, Linjuan; Wang, Zhongfu*; Wang, Chengjian*. Comprehensive comparison of bioactive N-glycans among seven species of livestock and poultry plasma using a relative quantification strategy. Journal of Agricultural and Food Chemistry, 2023, 71(48): 19088-1910. (SCI一区top)

（11）Wei, Ming; Huang, Linjuan; Liu, Yuxia; Jin, Wanjun; Yao, Xinbo; Rong, Jinqiao; Bai, Fan; Song, Xuezheng*; Wang, Zhongfu*. Strategy for isolation, preparation, and structural analysis of chondroitin sulfate oligosaccharides from natural sources. Analytical Chemistry, 2020, 92(17): 11644-11653. (SCI一区top)

（12）Zhong, Peiyun; Yang, Yuerong; Han, Tianjiao; Huang, Wenqi; Liu, Yuxia; Gong, Guiping; Huang, Linjuan; Lu, Yu*; Wang, Zhongfu*. Comparative Analysis of Free and Glycoconjugates Oligosaccharide Content in Milk from Different Species. Journal of Agricultural and Food Chemistry, 2024, 72(1): 670-678. (SCI一区top)

（13）Han, Jianli; Qinghui Chen; Jin, Wanjun; Zou, Meiyi; Lu, Yu; Liu, Yuxia; Wang, Chengjian; Wang, Zhongfu; Linjuan Huang*. Purification of N- and O-glycans and their derivatives from biological samples by the absorbent cotton hydrophilic chromatographic column. Journal of Chromatography A, 2020, 1620: 461001. (SCI二区)

（14）Huang, Wenqi; Xie Yutao; Guo, Tongyi; Dai, Wei; Nan, Linhua; Wang, Qian; Liu, Yuxia; Lan Wenxian; Wang, Zhongfu; Huang, Linjuan*; Guiping Gong*. A new perspective on structural characterisation and immunomodulatory activity of arabinogalactan in Larix kaempferi from Qinling Mountains. International Journal of Biological Macromolecules, 2024, 265: 130859. (SCI一区top)

（15）Zhao, Tong; Zhang, Yue; Nan, Linhua; Zhu, Qing; Wang, Shukai; Xie, Yutao; Dong, Xinling; Cao, Cui; Lin, Xiaoliang; Lu, Yu; Liu, Yuxia; Huang, Linjuan; Gong, Guiping*; Wang Zhongfu*. Impact of structurally diverse polysaccharides on colonic mucin O-glycosylation and gut microbiota. NPJ Biofilms Microbiomes, 2023, 9(1): 97. (SCI一区top)

（16）Li, Cheng; Han, Tianjiao; Zhong, Peiyun; Zhang, Yuyang; Zhao, Tong; Wang, Shukai; Wang, Xiaoqin; Tian, Yang; Gong, Guiping; Liu, Yuxia; Huang, Linjuan; Lu, Yu*; Wang, Zhongfu*. α2,6-linked sialylated oligosaccharides riched in goat milk alleviate food allergy by regulating the gut flora and mucin O-glycosylation. Carbohydrate Polymers, 2025, 350: 123049. (SCI一区top)

（17）Zou, Zihua; Wei, Ming; Fang, Jie; Dai, Wei; Sun, Tingting; Liu, Qian; Gong, Guiping; Liu, Yuxia; Song, Shuang; Ma, Fangli; Wang, Langhong; Huang, Linjuan*; Wang, Zhongfu*. Preparation of chondroitin sulfates with different molecular weights from bovine nasal cartilage and their antioxidant activities. International Journal of Biological Macromolecules, 2019, 592, 113355: 1-12. (SCI一区top)

（18）Gong, Guiping; Dang, Tiantian; Fang, Jie; Deng, Yangni; Liu, Qian; Dai,Wei; Sun, Jing; Wang, Langhong; Liu, Yuxia; Sun, Tingting; Song, Shuang; Fan, Luodi; Huang, Linjuan*; Wang, Zhongfu*. Preparation, structural characterization, and bioactivity of PHPD-IV-4 derived from Porphyra haitanensis. Food Chemistry, 2020, 329: 127042. (SCI一区top)

（19）Gong, Guiping; Liu, Qian; Deng, Yangni; Dang, Tiantian; Dai, Wei; Liu, Tingting; Liu, Yang; Sun, Jing; Wang, Langhong; Liu, Yuxia; Sun, Tingting; Song, Shuang; Wang, Zhongfu*; Huang, Linjuan*. Arabinogalactan derived from Lycium barbarum fruit inhibits cancer cell growth via cell cycle arrest and apoptosis. International Journal of Biological Macromolecules, 2020, 149: 639-650. (SCI一区top)

发明专利：

（1）刘玉霞，王仲孚，黄琳娟，龚桂萍，路宇。一种氰基吡唑啉酮类异二官能团试剂及其在构建糖芯片中的应用，ZL202215772380.7。

（2）王超，刘玉霞，薛东，肖建良。一种合成异喹啉酮类化物的方法，ZL201510534658.5。

（3）王超，刘玉霞，薛东，肖建良。一种合成异色酮类化合物的方法，ZL201610348233.X。

获奖情况：

[1] 第三届青年教师讲课比赛，食品科学与工程学院，优秀奖，2023年。

[2] 参与指导学生获得中国国际大学生创新大赛（2024），省级银奖，校级金奖，2024年。

[3] 暑期“三下乡”社会实践活动，荣获优秀指导教师，2024年。

[4] 第二届陕西省博士后创新创业大赛，优胜奖，陕西省人力资源社会保障厅，陕西，西安，2023年，3/6。