所属部门：食品科学与工程学院

职务/职称：副教授

荣誉：入选西安市科协青年人才托举计划；

2019年度陕西省营养与健康领域先进工作者

电子邮件：liuqian2017@nwu.edu.cn

个人简介：

刘茜，女，中共党员，工学博士，副教授，研究生导师。具有健康管理师、营养指导员资格证书，任陕西省营养学会理事。主要从事食品功能化学与营养方向研究，研究内容具体包括：膳食营养组分对神经退行性疾病及代谢综合征的干预作用；天然多糖生物活性及构效关系研究；营养健康食品制造。

近年来主持国家自然科学基金、陕西省重点研发计划-重点产业创新链项目、中国博士后面上项目、陕西省科技厅自然科学基础研究计划等科研项目8项，作为主要参与人参与陕西省中央引导地方科技发展专项资金项目、陕西省科技厅科技资源开放共享平台项目等5项。目前已在The FASEB Journal、Food Research International、Journal of Agricultural and Food Chemistry、Journal of Functional Foods、Food & Function等发表 SCI 论文 30 余篇。任Frontiers in Aging Neuroscience评审编辑，Frontiers in Nutrition专刊客座副主编。

研究成果：

一、科研项目

[1] 国家自然科学基金青年项目，32001697，2021/01-2023/12，主持；

[2] 中国博士后基金面上项目，2020M683542，2020/06-2022/06，主持；

[3] 陕西省重点研发计划-重点产业创新链（群），2023-ZDLNY-30，2023/01-2025/12，主持；

[4] 西安市科协青年人才托举计划项目，095920221370，2022/06-2024/06，主持；

[5] 陕西省科技厅自然科学基础研究计划一般项目，2019JQ-721，2019/01-2020/12，主持；

[6] 陕西省教育厅一般专项项目，20JK0936，2020/01-2021/12，主持；

[7] 西安市科学技术局农业技术研发项目，20NYYF0023，2020/04-2023/04，主持；

[8] 西北大学科研启动基金，338050045，2017/11-2019/11，主持；

[9] 陕西省中央引导地方科技发展专项资金项目，2022ZY2-CGZY-02，参与；

[10] 陕西省科技厅重点研发计划一般项目，2020NY-201，参与；

[11] 陕西省科技厅重点研发计划一般项目，2021SF-299，参与；

[12] 陕西省重点研发计划项目一般项目，2022NY-015，参与；

[13] 陕西省科技厅科技资源开放共享平台项目，2022PT-46，参与。

二、教学项目

[1] 新工科背景下《食品营养学》创新创业人才培养教学改革探索与实践，西北大学2022年“本科人才培养建设项目”，2022年，主持；

[2] 基于“云工坊”模式的食品学科产教融合创新实践平台建设探索与实践，2020年陕西省新工科研究与实践项目，2020年，参与；

[3] 《食品营养学》，XM05201461，西北大学课程思政建设专项（精品示范课程类），2020年，参与；

[4] 精品在线开放课程《食品营养学》MOOC，XM05191231，西北大学2019年度本科人才培养项目，2019年，参与。

三、教材/专著

[1]《食品营养学》（“十四五”普通高等教育本科规划教材），参编，科学出版社，2022。

四、代表性学术论文

[1] Qian Liu †, Jie Fang †, Wenqi Huang, Sining Liu, Xueting Zhang, Guiping Gong, Linjuan Huang, Xiaoliang Lin*, Zhongfu Wang *. The intervention effects of konjac glucomannan with different molecular weights on high-fat and high-fructose diet-fed obese mice based on the regulation of gut microbiota. Food Research International. 2023, 165: 112498.（IF₂₀₂₃ : 7.425，1区，TOP期刊）

[2] Qian Liu, Jie Fang, PanPan Chen, Yun Die, Jing Wang, Zhigang Liu, Xuebo Liu^*. Chicoric acid improves neuron survival against inflammation through promoting mitochondrial function and energy metabolism. Food & Function. 2019, 10(9), 6157-6169. （IF₂₀₁₉ : 4.171, 1区，TOP 期刊）

[3] Qian Liu, Yaya Hu, Youfang Cao, Ge Song, Zhigang Liu^*, Xuebo Liu^*. Chicoric Acid ameliorates lipopolysaccharide induced oxidative stress via promoting Keap1/Nrf2 transcriptional signaling pathway in BV-2 microglial cells and mice brain. Journal of Agricultural and Food Chemistry. 2017, 65(2):338-347.（IF₂₀₁₇ : 3.412，1区，TOP 期刊，高被引）

[4] Qian Liu, Fan Liu, Liling Zhang, Yajie Niu, Zhigang Liu, Xuebo Liu^*. Comparison of chicoric acid, and its metabolites caffeic acid and caftaric acid: in vitro protection of biological macromolecules and inflammatory responses in BV2 microglial cells. Food Science and Human Wellness. 2017, 6(4):155-166.（1区，TOP 期刊）

[5] Qian Liu^#, Yutang Wang^#, ChunXia Xiao, Wanqiang Wu, Xuebo Liu^*. Metabolism of chicoric acid by rat liver microsomes and bioactivity comparisons of chicoric acid and its metabolites. Food & Function. 2015, 6(6):1928-1935.（IF₂₀₁₅ : 2.686, 1区，TOP 期刊）

[6] Qian Liu, Yuwei Chen, Chun Shen, Yating Xiao, Yutang Wang, Zhigang Liu^*, Xuebo Liu^*. Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB. FASEB Journal. 2017, 31(4):1494-1507. （IF₂₀₁₇ : 5.595，2区，TOP 期刊）

[7] Qian Liu †*, Xin An †, Yuan Chen, Yuxuan Deng, Haili Niu, Ruisen Ma, Haoan Zhao, Wei Cao, Xiaoru Wang, Meng Wang. Effects of Auricularia auricula polysaccharides on gut microbiota and metabolic phenotype in mice. Foods. 2022, 11(17): 2700.（IF₂₀₂₂ : 5.561，2区）

[8] Qian Liu *†, Ruisen Ma †, Si Li, Yujie Fei, Jing Lei, Ruoyu Li, Yu Pan, Sining Liu and Langhong Wang. Dietary supplementation of auricularia auricula-judae polysaccharides alleviate nutritional obesity in mice via regulating inflammatory response and lipid metabolism. Foods. 2022, 11(7), 942.（IF₂₀₂₂ : 5.561，2区）

[9] 刘茜，李若雨，刘思宁，陈盼盼，方 洁，汪浪红，龚桂萍，王仲孚，黄琳娟. 魔芋葡甘露聚糖对高热能膳食诱导小鼠认知功能障碍及脑部氧化应激状态的影响. 食品科学. 2022,43(15):166-175. （EI/北大核心）

[10] 刘茜，张馨语，王琰，王安宇，赵艺，龙子仙，刘思宁，牒云，黄琳娟. 秦巴山区黑木耳多糖理化性质及体外抗氧化活性研究. 食品与发酵工业. 2021, 47( 23) :91-97. （北大核心）

[11] Tingting Liu, Wenqi Huang, Tong Zhao, Linhua Nan, Jing Sun, Qian Liu, Linjuan Huang, Xiaoliang Lin, Guiping Gong, Zhongfu Wang. Comparative analysis of the physicochemical properties and biological activities of Ziziphus Jujuba cv. Goutouzao polysaccharides obtained by fractional precipitation. Journal of Food Measurement and Characterization, 2023, 17(1): 1046-1057.

[12]Bing Xia, Xiaoning Liu,   Xiaohan Li,  Yutang Wang,  Danna Wang,   Rongwei Kou, Li Zhang,  Renjie Shi,  Jin Ye, Xiaowei Bo,  Qian Liu,   Beita Zhao  * and  Xuebo Liu  *. Sesamol ameliorates dextran sulfate sodium-induced depression-like and anxiety-like behaviors in colitis mice: the potential involvement of the gut–brain axis. Food & Function, 2022, 13(5): 2865-2883.

[13] Tingting Sun， Yang Liu， Wenqi Huang， Ye Li，Guiping Gong， Wenbing Zhi，Qian Liu，Zhongfu Wang，Linjuan Huang*，Hong Zhang*. Purification, structural characterization and immunoregulatory mechanism of PSPW-3-a isolated from wine-processed Polygonatum sibiricum. Journal of Functional Foods. Journal of Functional Foods, 2022, 95: 105159.

[14] Guiping Gong, Tiantian Dang, Jie Fang, Yangni Deng, Qian Liu, Wei Dai, Jing Sun，Langhong Wang，Yuxia Liu, Tingting Sun, Shuang Song, Luodi Fan, Linjuan Huang*, Zhongfu Wang*. Preparation, Structural Characterization and Bioactivity of PHPD-IV-4 derived from Porphyra haitanensis. Food Chemistry, 2020, 329, 127042.

[15] Guiping Gong, Qian Liu, Yangni Deng, Tiantian Dang, Wei Dai, Tingting Liu, Yang Liu, Jing Sun, Langhong Wang, Yuxia Liu, Tingting Sun, Shuang Song, Zhongfu Wang^*, Linjuan Huang^*. Arabinogalactan derived from Lycium barbarum fruit inhibits cancer cell growth via cell cycle arrest and apoptosis. International Journal of Biological Macromolecules, 2020, 149(15): 639-650.

[16] Tingting Sun, Hong Zhang, Ye Li, Yang Liu, Wei Dai, Jie Fang, Cui Cao, Yun Die, Qian Liu, Chunliu Wang, Lintao Zhao, Guiping Gong, Zhongfu Wang*, Linjuan Huang*. Physicochemical properties and immunological activities of polysaccharides from both crude and wine-processed Polygonatum sibiricum. International Journal of Biological Macromolecules, 2020, 143(15), 255-264.

[17] Zihua Zou^#, Ming Wei^#, Jie Fang, Wei Dai, Tingting Sun, Qian Liu, Guiping Gong,Yuxia Liu, Shuang Song, Fangli Ma, Langhong Wang, Linjuan Huang, Zhongfu Wang^*. Preparation of chondroitin sulfates with different molecular weights from bovine nasal cartilage and their antioxidant activities. International Journal of Biological Macromolecules, 2020, 152: 1047-1055.

[18] Yangni Deng, Qian Liu, Tiantian Dang, Guiping Gong, Xiaoyi Chen, Rui Tang, JingSun, Shuang Song, Linjuan Huang*, Zhongfu Wang*. Preparation, Structural Characterization and Bioactivity of 4-O-Methylglucuronoxylan from Artemisia sphaerocephala Krasch. Carbohydrate Polymers, 2019, 222: 115009.

[19] Rui Tang, Xiaoyi Chen, Tiantian Dang, Yangni Deng, Zihua Zou, Qian Liu, Guiping Gong, Shuang Song, Fangli Ma, Linjuan Huang* and Zhongfu Wang*. Lycium barbarum polysaccharides extend the mean lifespan of Drosophila melanogaster. Food & Function. 2019, 10(7), 4231-4241.

[20] Xiaoyi Chen, Rui Tang, Tingting Liu, Wei Dai, Qian Liu, Guiping Gong, Shuang Song, Minghua Hu , Linjuan Huang^*, Zhongfu Wang^*. Physicochemical properties, antioxidant activity and immunological effects in vitro of polysaccharides from Schisandra sphenanthera and Schisandra chinensis. International Journal of Biological Macromolecules. 2019, 131:744-751.

[21] Jing Wang, Qian Liu, Haifang Xiao, Xingxing Luo, Xuebo Liu^*. Suppressive effects of Momordin Ic on HepG2 cell migration and invasion by regulating MMP-9 and adhesion molecules: Involvement of p38 and JNK pathways. Toxicology in Vitro. 2019,56:75-83.

[22] Jia Wang, Lixia Li, Zhuo Wang, Yifan Cui, Xintong Tan, Tian Yuan, Qian Liu, Zhigang Liu^*, Xuebo Liu^*. Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress. Journal of Nutritional Biochemistry. 2018, 56: 16-25.

[23] Guiping Gong, Tiantian Dang, Yangni Deng, Jianli Han, Zihua Zou, Sun Jing, Ying Zhang, Qian Liu, Linjuan Huang, Zhongfu Wang^*. Physicochemical properties and biological activities of polysaccharides from Lycium barbarum prepared by fractional precipitation. International Journal of Biological Macromolecules. 2018, 109: 611-618.

[24] Zhijun Diao, Jing Li, Qian Liu, Yutang Wang^*. In-vivo metabolite profiling of chicoric acid in rat plasma, urine and feces after oral administration using liquid chromatography quadrupole time of flight mass spectrometry. Journal of Chromatography B. 2018, 8-14:1081-1082.

[25] Zhigang Liu^#, Yuwei Chen^#, Qinglian Qiao, Yali Sun, Qian Liu, Bo Ren, Xuebo Liu^*. Sesamol supplementation prevents systemic inflammation-induced memory amyloidogenesis via inhibition of nuclear factor kappaB. Molecular Nutrition & Food Research. 2017, 61(5):1600734.

[26] Zhigang Liu^#, Yali Sun^#, Qinglian Qiao, Tong Zhao, Wentong Zhang, Bo Ren, Qian Liu, Xuebo Liu^*. Sesamol ameliorates high-fat and high-fructose induced cognitive defects via improving insulin signaling disruption in the central nervous system. Food & Function. 2017, 8(2):710-719.

[27] Ge Song, Zhigang Liu, Qian Liu, Xuebo Liu^*. Lipoic acid prevents acrylamide-induced neurotoxicity in CD-1 mice and BV2 microglial cells via maintaining redox homeostasis. Journal of Functional Foods. 2017, 35:363–375.

[28] Yutang Wang^#, Zhijun Diao^#, Jing Li, Bo Ren, Di Zhu, Qian Liu, Zhigang Liu, Xuebo Liu^*. Chicoric acid supplementation ameliorates cognitive impairment induced by oxidative stress via promotion of antioxidant defense system. RSC Advances. 2017, 7(57):36149-36162.

[29] Yuting Cui, Peiran Lu, Ge Song, Qian Liu, Di Zhu, Xuebo Liu*. Involvement of PI3K/Akt, ERK and p38 signaling pathways in emodinmediated extrinsic and intrinsic human hepatoblastoma cell apoptosis. Food and Chemical Toxicology. 2016, 92: 26-37.

[30] Li Yuan, Jing Wang, Wanqiang Wu, Qian Liu, Xuebo Liu*. Effect of isoorientin on intracellular antioxidant defence mechanisms in hepatoma and liver cell lines. Biomedicine & Pharmacotherapy. 2016, 81, 356-362.

[31] Yutang Wang^#, Guo Xie^#, Qian Liu, Xiang Duan, Zhigang Liu, Xuebo Liu^*. Pharmacokinetics, tissue distribution, and plasma protein binding study of chicoric acid by HPLC-MS/MS. Journal of Chromatography B. 2016, 1031 (15): 139–145.

[32] Yutang Wang, Laping Liu, Chunxia Xiao, Lin Chen, Peng Yang, Qian Liu, Jianlong Wang, Xuebo Liu*. Rapid determination of trace sulfonamides in milk by graphene oxide based magnetic solid phase extraction coupled with HPLC–MS/MS. Food Analytical Methods. 2016, 9(9): 2521-2530.

[33] Li Yuan, Yuchen Wu, Xiaomeng Ren, Qian Liu, Jing Wang, Xuebo Liu*. Isoorientin attenuates lipopolysaccharide-induced pro-inflammatory responses through down-regulation of ROS-related MAPK/NF-κB signaling pathway in BV-2 microglia. Molecular and Cellular Biochemistry. 2014, 386:153-165.

[34] Qisen Xiang, Qian Liu, Li Xu, Yan Qiao, Yutang Wang, Xuebo Liu*. Carnosic acid protects biomolecules from free radical-mediated oxidative damage in vitro. Food Science and Biotechnology. 2013, 22(5): 1381-1388.

[35] 秦嘉乐; 李重言; 刘茜; 张颖; 汪浪红; 曾新安. 等离子体处理对小米内源酶活性及其品质的影响. 现代食品科技, 2022,38(08):66-72.

[36] 张月, 刘茜, 肖春霞. 辣椒碱对生物大分子氧化损伤的保护作用. 现代食品科技. 2017, 33(2):41-47.

[37] 张亦凡, 刘功关, 刘茜, 刘学波. 圣草酚抑制自由基诱导的生物大分子损伤及对肝癌细胞HepG2毒性的作用. 食品科学. 2013, 34(17): 126-130.

获奖情况：

一、科研获奖

[1] 陕西省科学技术奖二等奖，陕西省人民政府，2019年，6/7。

二、教学获奖

[1] 参与指导学生获得“陕西省第一届营养食品创新创意大赛”一等奖，2019年

[2] 首届青年教师讲课比赛，食品科学与工程学院，二等奖，2019年

[3] 参与指导学生获得第六届中国国际 “互联网+” 大学生创新创业大赛，省级铜奖，2020年

[4] 第二届青年教师讲课比赛，食品科学与工程学院，二等奖，2020年

[5] 第三届课堂教学创新大赛，食品科学与工程学院，二等奖，2021年

[6] 参与指导学生获得第八届中国国际“互联网+”大学生创新创业大赛，省级铜奖，2022年